关健

姓名：关健

性别：男

籍贯：辽宁沈阳

政治面貌：群众

联系邮箱：guanjian2621@163.com

研究方向：

难溶性药物递送系统（无定形固体分散体及纳米晶）

纳米递药系统（脂质纳米粒、纳米乳剂）

过饱和递药系统

无定形固体分散体结晶抑制及其机理的探究

经鼻脑靶向递药系统（中枢神经系统药物）

肺部递药系统 (干粉吸入剂， DPI)

药用辅料粉体学性质研究

职称：讲师

学习/工作经历：

2021/07-至今 威廉希尔-鲁南制药集团联合培养博士后

2020/05-至今 威廉希尔 药剂教研室 讲师/特聘副研究员/硕士研究生导师

2019/11 威廉希尔 药剂学 （博士）

2018/10-2019/10 美国普度大学 联合培养博士生

2015/09-2019/12 威廉希尔 药剂学 （博士）

2012/09-2015/6 威廉希尔 药剂专硕（硕士）

2007/09-2011/7 威廉希尔 药物制剂（学士）

所获荣誉：

1. 基于智能生物可降解高分子载体的创新递药系统设计与评价 辽宁省自然科学二等奖（3/5）

2. 《Influence of stabilizer type and concentration on the lung deposition and retention of resveratrol nanosuspension-in-microparticles》辽宁省自然科学学术成果奖 二等奖 （2/5）

3. 指导员工参加第十届辽宁省老员工创新创业年会获得年会作品二等奖

科研成果：

主要科研项目

1. Gal-3受体靶向过饱和递药系统诱导小胶质细胞M1-M2转型逆转帕金森中枢炎症探讨（国家自然科学基金-青年基金，30 万元，主持，82204313）

2. 经鼻小胶质细胞靶向过饱和药物聚集体递送系统的构建及抗帕金森病探讨（山东省博士后创新项目，5万元，主持，SDCX-ZG-202202008）

3. 纳米抗体干粉吸入剂的制备与评价（威廉希尔-上海洛启生物医药有限公司，横向课题，15万元，主持）

4. 催产素鼻用制剂的制备与评价（威廉希尔-沈阳科硕商贸有限公司，横向课题，15万元，主持）

5. 活性物质NRB静脉注射剂实验室处方工艺研究（威廉希尔-中国医学科学院药用植物研究所，横向课题，5万元，主持）

6. 国家药典委员会药品标准提高课题-药用辅料粉体流动性评价方法（参与，该方法已收载至2025版中国药典）

7. 国家药典委员会药品标准提高课题-剪切池法评价药用辅料粉体学性质（课题承担人）

发表文章

专利:

1. Mao S, Guan J, Helgerud T, Zhang Y. Solid dispersions (WO2016/145132 A1, FMC Biopolymer cooperation).

2. Guan J, Mao S, Helgerud T, Zhang Y. Nanosuspension formulation (WO2016/081593 A1, FMC Biopolymer cooperation).

3. 毛世瑞，关健，张欣，一种拉西地平固体分散体及其制备方法 (201910067325.4，已授权)。

专著章节:

Chapter 15: Guan J, Li L, Mao S. Applications of Carrageenan in Advanced Drug Delivery, Seaweed Polysaccharide 283-298 (Elsevier, edited by Jayachandran Venkatesan, Sukumaran Anil and SE-Kwon Kim).

Chapter 2: Guan J, Mao S. Pharmaceutical applications of Gum Arabic, Natural Polymer for Pharmaceutical Applications (in production, Apple Academic Press, edited by Amit Kumar Nayak, Md Saquib Hasnain and Dilipkumar Pal).

研究性论文:

1. Guan J, Yuan H, Yu S, Mao S, Tony Zhou Q. 2022 Spray dried inhalable ivacaftor co-amorphous microparticle formulations with leucine achieved enhanced in vitro dissolution and superior aerosol performance, International Journal of Pharmaceutics (DOI: 10.1016/j.ijpharm.2022.121859, IF 5.8).

2. Guan J, Liu Q, Jin L, Huan X , Wu H, Zhang X, Mao S. 2019 Synergistic effect of Soluplus and hyaluronic acid on the supersaturation maintenance of lovastatin: The facilitated in vitro-in vivo performance and improved physical stability, Carbohydrate Polymers 222 (DOI: 10.1016/j.carbpol.2019.114978, IF 7.182).

3. Guan J, Liu Q, Liu J, Cui Z, Zhang X, Mao S. 2019 Elucidation of alginate-drug miscibility on its crystal growth inhibition effect in supersaturated drug delivery system, Carbohydrate Polymer 230 (DOI: 10.1016/j.carbpol.2019.115601, IF 9.381).

4. Guan J, Huan X, Liu Q, Jin L, Wu H, Zhang X, Mao S. 2019 Synergetic effect of nucleation and crystal growth inhibitor on in vitro-in vivo performance of supersaturable lacidipine solid dispersion, International Journal of Pharmaceutics 566: 594-603 (IF 4.845).

5. Guan J, Liu Q, Zhang X, Zhang Y, Chokshi R, Wu H, Mao S. 2017 Alginate as a Potential Diphase Solid Dispersion Carrier with enhanced drug dissolution and improved storage stability, European Journal of Pharmaceutical Sciences 114, 346-355 (DOI: 10.1016/j.ejps.2017.12.028, IF 3.466).

6. Guan J, Jin L, Liu Q, Huan X. Exploration of supersaturable lacidipine ternary amorphous solid dispersion for enhanced dissolution and in vivo absorption, European Journal of Pharmaceutical Sciences 139 (IF 3.616).

7. Guan J, Zhang Y, Liu Q, Zhang X, Chokshi R, Mao S. 2017 Exploration of alginates as potential stabilizers of nanosuspension, AAPSPharmSciTech 18(8):3172-3181 (DOI: 10.1208/s12249-017-0801-6, IF 2.666).

8. Liu Q, Guan J, Qin L, Zhang X, Mao S. 2020 Physicochemical properties affecting the fate of nanoparticles in pulmonary drug delivery, Drug Discovery Today, 25( 1):150-159 (DOI: 10.1016/j.drudis.2019.09.023).

9. Zhang X, Guan J, Ni R, Li LC, Mao S. 2014 Preparation and solidification of redispersible nanosuspensions, Journal of Pharmaceutical Sciences 103 (7):2166-2176 (DOI: 10.1002/jps.24015).

10. Liu Q, Guan J, Sun Z, Shen X, Li L, Jin L, Mao S. Influence of stabilizer type and concentration on the lung deposition and retention of resveratrol nanosuspension-in-microparticles, International Journal of Pharmaceutics 569 (DOI: 10.1016/j.ijpharm.2019.118562).

11. Zhang X, Cheng H, Dong W, Zhang M, Liu Q, Wang X, Guan J, Wu H, Mao S. 2017 Design and intestinal mucus penetration mechanism of core-shell nanocomplex, Journal of Controlled Release 28;272:29-38 (DOI: 10.1016/j.jconrel.2017.12.034).

12. Wang L, Sun Y, Shi C, Li L, Guan J, Zhang X, Ni R, Duan X, Li Y, Mao S. 2014 Uptake, transport and peroral absorption of fatty glyceride grafted chitosan copolymer-enoxaparin nanocomplexes: influence of glyceride chain length, Acta Biomaterial 10(8):3675-85 (DOI: 10.1016/j.actbio.2014.05.003).

会议摘要:

1. Guan J, Liu Q, Zhang Y. 2017Alginate as a Potential Solid Dispersion Carrier Prepared by Kneading Method (Formula IX, Beijing).

2. Guan J, Liu Q, Zhang X, Mao S. 2017 Influence of Drug-Alginate Miscibility and Alginate Properties on the Crystal Inhibiting Effect (AAPS annual meeting, San Diego).

3. Guan J, Liu Q, Mao S. 2016 Alginates as novel stabilizers of nanosuspension (AAPS annual meeting, Denver).

4. Guan J, Liu Q, Zhang Y. Mao S. 2016 Application of alginate as solid dispersion carrier to enhance solubility of poorly soluble drugs (AAPS annual meeting, Denver).

指导研究生情况：目前在读研究生10名