邓意辉

姓名：邓意辉

性别：男

籍贯：湖南花垣

政治面貌：中国民主同盟盟员

联系邮箱：101030106@syphu.edu.cn

研究方向：

研究方向一：ABC现象及其机制与解决方案的研究

研究方向二：疾病相关细胞（群）与治疗新策略的探索

研究方向三：免疫药剂学，包括疾病大环境与微环境，溶酶体主动逃逸，跨代遗传等等。

职称：教授

学习/工作经历：

1985年毕业于西安交通大学威廉希尔足球（原西安医学院药学系），获药学士学位，1992年于威廉希尔获药剂学硕士学位，1999年于同校获药剂学博士学位。2005年被聘为威廉希尔教授。

所获荣誉：

作为课题负责人主持或参与了国家自然科学基金项目6项，十一五重大项目1项、辽宁省科技厅科研项目1项，省科委研究项目2项、广东省课题1项及市委课题2项、获得辽宁省科学技术奖励一等奖。

科研成果：

1. Dezhi Sui; Yanzhi Song; Yihui Deng. Combination therapy with lipid prodrug liposomes reshapes disease-associated neutrophils to promote the cancer-immunity cycle. Journal of Nanobiotechnology 2025, 23, 1 -20.（IF=10.2）

2. Yantong Li; Shuo Wang; Xinying Guan; Senyu Zhang; Rui Yang; Mingze Li; Tingyan Liu; Jingyi Zhao; Lin Lin; Xinrong Liu; Yanzhi Song; Yihui Deng. Sialic acid-modified nanomedicines modulate neutrophils for dual therapy of cancer and sepsis: addressing neglected sepsis comorbidities during cancer treatment. International Journal of Pharmaceutics 2025, 671, 125211 .（IF=5.8）

3. Jiawei Lian; Xueying Tang; Yangxu Gui; Shuang Lu; Yanzhi Song; Yihui Deng. Impact of formulation parameters and circulation time on PEGylated liposomal doxorubicin related hand-foot syndrome. International Journal of Pharmaceutics 2024, 665, 124659 .（IF=5.8）

4. Tiantian Guo; Yu Wang; Dazhi Wang; Ruirui Ge; Zhouchunxiao Du; Zhirong Zhang; Yushi Qin; Xinrong Liu; Yihui Deng; Yanzhi Song. Sialic acid-modified docetaxel cationic liposomes: double targeting of tumor-associated macrophages and tumor endothelial cells. Journal of Liposome Research 2024, 1 -15.(IF=4.4)

5. Dazhi Wang; Yanmei Kou; Tiantian Guo; Lili Duan; Jiepeng Chen; Chunxiao Duzhou; Tiancheng Huang; Xinrong Liu; Yihui Deng; Yanzhi Song. Intravenous injection of nattokinase-heparin electrostatic complex improves the therapeutic effect of advanced tumors by dissolving cancer-related thrombosis. Life Sciences 2024, 355, 122935 .(IF=6.1)

6. Jingyi Zhao; Kunfeng Zhang; Dezhi Sui; Shuo Wang; Yantong Li; Xueying Tang; Xinrong Liu; Yanzhi Song; Yihui Deng. Recent advances in sialic acid-based active targeting chemoimmunotherapy promoting tumor shedding: a systematic review. Nanoscale 2024, 16, 14621 -14639.（IF=6.7）

7. Dezhi Sui; Kaituo Zhang; Zhaowei Qi; Mingze Li; Zhouchunxiao Du; Dazhi Wang; Changzhi Li; Xinrong Liu; Yanzhi Song; Yihui Deng. Transformable binary-prodrug nanoparticles harness heterogeneity of neutrophils to overcome multidrug resistance and promote pyroptosis in cancer. Applied Materials Today 2024, 37 .(IF=8.3)

8. Wenliang Sun; Chao Han; Ruirui Ge; Xiaotong Jiang; Yu Wang; Yingchao Han; Ning Wang; Yanzhi Song; Mingshi Yang; Guoliang Chen; Yihui Deng. Sialic Acid Conjugate-Modified Cationic Liposomal Paclitaxel for Targeted Therapy of Lung Metastasis in Breast Cancer: What a Difference the Cation Content Makes. Molecular Pharmaceutics 2024, 21, 1625 -1638.(IF=4.9)

9. Xueying Tang; Jiashuo Zhang; Dezhi Sui; Zihan Xu; Qiongfen Yang; Tianyu Wang; Xiaoya Li; Xinrong Liu; Yihui Deng; Yanzhi Song. Durable protective efficiency provide by mRNA vaccines require robust immune memory to antigens and weak immune memory to lipid nanoparticles. Materials Today Bio 2024, 25, 100988 .(IF=8.2)

10. Xueying Tang; Jiashuo Zhang; Dezhi Sui; Qiongfen Yang; Tianyu Wang; Zihan Xu; Xiaoya Li; Xin Gao; Xinyang Yan; Xinrong Liu; Yanzhi Song; Yihui Deng. Simultaneous dendritic cells targeting and effective endosomal escape enhance sialic acid-modified mRNA vaccine efficacy and reduce side effects. Journal of Controlled Release 2023, 364, 529 -545.(IF=10.8)

11. Zhouchunxiao Du; Dezhi Sui; Dongzhe Xin; Xueying Tang; Mingze Li; Xinrong Liu; Yihui Deng; Yanzhi Song. Sialic acid-modified doxorubicin liposomes target tumor-related immune cells to relieve multiple inhibitions of CD8 + T cells. Journal of Liposome Research 2024, 34, 464 -474.(IF=4.4)

12. Lu Wei; Lin Lin; Jia Wang; Xinying Guan; Wen Li; Yangxu Gui; Shupei Liao; Mingyang Wang; Jiaqi Li; Yihui Deng; Yanzhi Song. The selection of animal models influences the assessment of anti-tumor efficacy: promising sialic acid-conjugate modified liposomes demonstrate remarkable therapeutic effects in diverse mouse strains. Drug Delivery and Translational Research 2024, 14, 1794 -1809.(IF=5.4)

13. Dezhi Sui; Yujie Wang; Wenliang Sun; Lu Wei; Changzhi Li; Yangxu Gui; Zhaowei Qi; Xinrong Liu; Yanzhi Song; Yihui Deng. Cleavable-Branched Polymer-Modified Liposomes Reduce Accelerated Blood Clearance and Enhance Photothermal Therapy. ACS Applied Materials & Interfaces 2023, 15, 32110 -32120.(IF=9.5)

14. Zhaowei Qi; Jia Shi; Yanzhi Song; Yihui Deng. A novel micellar carrier to reverse multidrug resistance of tumours: TPGS derivatives with end-grafted cholesterol. Journal of Drug Targeting 2023, 31, 537 -553.(IF=4.5)

15. Meng Chen; Zhaowei Qi; Xianmin Meng; Shuo Wang; Xueying Zheng; Miao Hu; Xinrong Liu; Yanzhi Song; Yihui Deng. Blockade of neutrophil recruitment to tumor sites based on sialic acid-modified nanoplatforms enhances the efficacy of checkpoint blockade immunotherapy. Asian Journal of Pharmaceutical Sciences 2023, 18, 100784 .(IF=10.2)

16. Xianmin Meng; Hongxia Zhang; Lingyan Chen; Mingqi Wang; Kaituo Zhang; Xinrong Liu; Yihui Deng; Yanzhi Song. Liposomal Doxorubicin: the Sphingomyelin/Cholesterol System Significantly Enhances the Antitumor Efficacy of Doxorubicin. AAPS PharmSciTech 2023, 24, 1 -12.(IF=3.3)

17. Wenliang Sun; Yantong Li; Dezhi Sui; Zhaowei Qi; Xinran Zhao; Wei Zhou; Huiguo Hu; Xinrong Liu; Yanzhi Song; Yihui Deng. A potential platform of combining sialic acid derivative-modified paclitaxel cationic liposomes with antibody–drug conjugates inspires robust tumor-specific immunological memory in solid tumors. Biomaterials Science 2023, 11, 2787 -2808.(IF=6.6)

18. Shuo Wang; Yuequan Wang; Xiaoxue Lai; Jianwen Sun; Miao Hu; Meng Chen; Cong Li; Feng Xu; Chuizhong Fan; Xinrong Liu; Yanzhi Song; Guoliang Chen; Yihui Deng. Minimalist Nanocomplex with Dual Regulation of Endothelial Function and Inflammation for Targeted Therapy of Inflammatory Vascular Diseases. ACS Nano 2023, 17, 2761 -2781.(IF=17.1)

19. Lu Wei; Dan Zhao; Wenliang Sun; Lin Lin; Dezhi Sui; Wen Li; Yangxu Gui; Jia Wang; Yihui Deng; Yanzhi Song. Targeting of TAMs with freeze-dried monosialotetrahexosylganglioside and sialic acid-octadecylamine co-modified liposomes remodels the tumor microenvironment and enhances anti-tumor activity. European Journal of Pharmaceutics and Biopharmaceutics 2023, 184, 50 -61.(IF=4.9)

20. Meng Chen; Shuo Wang; Zhaowei Qi; Xianmin Meng; Miao Hu; Xinrong Liu; Yanzhi Song; Yihui Deng. Deuterated colchicine liposomes based on oligomeric hyaluronic acid modification enhance anti-tumor effect and reduce systemic toxicity. International Journal of Pharmaceutics 2022, 632, 122578 .(IF=5.8)

21. Xinyang Yan; Xin Gao; Xiaoya Li; Qiujun Qiu; Cong Li; Na Yan; Jie Li; Mengyang Liu; Xueying Tang; Xinrong Liu; Yanzhi Song; Yihui Deng. Persistent immune response: Twice tumor exfoliation induced by sialic acid–modified vincristine sulfate liposomes. International Journal of Pharmaceutics 2022, 631, 122467 . (IF=5.8)

22. Cong Li; Chuizhong Fan; Shuang Lu; Qiujun Qiu; Xin Gao; Xinyang Yan; Shuo Wang; Bing Zhao; Xinrong Liu; Yanzhi Song; Yihui Deng. Targeting Ibrutinib to Tumor-Infiltrating T Cells with a Sialic Acid Conjugate-Modified Phospholipid Complex for Improved Tumor Immunotherapy. Molecular Pharmaceutics 2022, 20, 438 -450.(IF=4.9)

23. Dezhi Sui; Changzhi Li; Xueying Tang; Xianmin Meng; Junqiang Ding; Qiongfen Yang; Zhaowei Qi; Xinrong Liu; Yihui Deng; Yanzhi Song. Sialic acid-mediated photochemotherapy enhances infiltration of CD8+ T cells from tumor-draining lymph nodes into tumors of immunosenescent mice. Acta Pharmaceutica Sinica B 2022, 13, 425 -439.(IF=14.5)

24. Chuizhong Fan; Cong Li; Shuang Lu; Xiaoxue Lai; Shuo Wang; Xinrong Liu; Yanzhi Song; Yihui Deng. Polysialic Acid Self-assembled Nanocomplexes for Neutrophil-Based Immunotherapy to Suppress Lung Metastasis of Breast Cancer. AAPS PharmSciTech 2022, 23, 1 -13.(IF=3.3)

25. Meng Chen; Wenjing Wu; Shuo Wang; Xiaoxue Lai; Mengyang Liu; Yiming Sun; Xinrong Liu; Gang Li; Yanzhi Song; Changshun Bao; Xiaohu Li; Guoliang Chen; Yihui Deng. Neutrophils as emerging immunotherapeutic targets: Indirect treatment of tumors by regulating the tumor immune environment based on a sialic acid derivative-modified nanocomplex platform. International Journal of Pharmaceutics 2022, 620, 121684 . (IF=5.8)

26. Mengyang Liu; Yuqing Su; Meng Chen; Jia Wang; Min Liu; Yueying Dai; Chunling Wang; Xiang Luo; Chaoyang Lai; Mingqi Liu; Junqiang Ding; Cong Li; Yawei Hu; Xueying Tang; Xinrong Liu; Yihui Deng; Yanzhi Song. A preliminary study of the innate immune memory of Kupffer cells induced by PEGylated nanoemulsions. Journal of Controlled Release 2022, 343, 657 -671. (IF=10.8)

指导研究生情况：

近五年指导硕士研究生49人、博士研究生10人，目前在读硕士研究生20人，在读博士研究生4人。

其他：

1.邓意辉，周松雷，张婷，彭博，刘欣荣，宋艳志，刘洋，胡玲，一种含有唾液酸基因的脂质衍生物的合成及其在药物制剂中的应用. 201610533120.7

2.邓意辉，佘振南，张婷，宋艳志，程晓波，欧瀚杰，一种含有唾液酸基团的脂质衍生物及其应用.201310067403.3

3.邓意辉，宋艳志，田清菁，刘欣荣，王旭玲，苏钰清，全晶晶，李博群，PSA-TPGS偶联物及应用.201610457682.8

4.邓意辉，宋艳志，刘欣荣，田清菁，隋月，蒋宫平，程晓波，胆固醇-泊洛沙姆-胆固醇三嵌段共聚物及其制备方法和应用.201310181525.5

5.邓意辉，程晓波，王春玲，王宇，付强，可消除TPGS起昙现象的组合物及其在药物制剂中的应用.201210456014.5

6.邓意辉，程晓波，王春玲，王宇，付强，可消除HS15起昙现象的组合物及其在药物制剂中的应用.201210455793.7

7.邓意辉，程晓波，王春玲，张婷，付强，可消除Tween类表面活性剂起昙现象的组合物.201210456298.8

8.邓意辉，徐洋，佘振南，一种含有小檗胺类药物的脂质体制剂及其制备方法.201110453572.1

9.邓意辉，宋艳志，田清菁，范迪，黄振君，刘欣荣，张婷，全晶晶，程晓波，佘振南， 聚乙二醇维生素E琥珀酸酯-胆固醇碳酸酯的合成及其制备方法和应用.201410056873.4

10.邓意辉，何琳，佘振南，吉非替尼的苹果酸加成盐及其制备和应用.201110431321.3

一种马来酸匹杉琼的脂质体制剂及其制备工艺 - 201210195910.0

吉非替尼脂质体制剂及其制备方法 - 201110453578.9

一种制备具有内外水相梯度差囊泡的装置及方法 - 201110183477.4

有权

申请人：威廉希尔 - 申请日：2011-07-01 - 主分类号：A61J3/00(2006.01)I

发明人：邓意辉;佘振南;程晓波;杨强;何琳;徐洋;翟文...

低浓度PEG脂质衍生物及其应用 - 201110153696.8

有权

申请人：威廉希尔 - 申请日：2011-06-09 - 主分类号：A61K47/34(2006.01)I

发明人：邓意辉;王龙;赵永雪;严米娜;王春玲;马艳玲;...

一种含有二甲双胍囊泡类给药系统及其应用 - 201110105030.5

有权

申请人：威廉希尔 - 申请日：2011-04-26 - 主分类号：A61K9/127(2006.01)I

发明人：邓意辉;杨强;张小飞...

利用离子交换纤维制备具内外水相梯度差的脂质体及其应用 -201010565390.9

有权

申请人：威廉希尔 - 申请日：2010-11-30 - 主分类号：A61K9/127(2006.01)I

发明人：邓意辉;杨强...